Guppy Tank: Episode 10

February 13, 2018

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Location: Lobby
Time: 4:00PM-6:00PM


Guppy Tank is back and better than ever!

The partnership between Harvard University's Office of Technology Development and LabCentral has found you two more innovative teams to present at Guppy Tank episode 10. Two early-stage life-science projects will pitch their innovation concepts to a panel of entrepreneurs and investors for constructive, in-depth feedback regarding application priorities and their commercialization models. Come and be inspired!

Innovation Team 1
Traversing the Great Barrier
Prof. Samir Mitragotri, Harvard University

Oral delivery of proteins is a holy grail of drug delivery and is becoming more relevant as the number of biologics-based therapies keeps increasing. The intestinal epithelium represents an insurmountable and formidable obstacle for systemic absorption after oral delivery.  Using Insulin as a representative and efficacious example, we describe an ionic-liquid based approach to deliver biologics across this great barrier.  The tunable nature of our delivery system allows us to extend this to other biologics including larger proteins and antibodies.

The team is seeking feedback regarding application/indication priorities and strategies, commercial strategy, and potential partnerships.

Innovation Team 2
Neurobiotics - Blocking nerves to treat infection
Prof. Isaac, Chiu, Harvard Medical School

Based on our exciting finding that the nervous system plays a key role in regulating the immune response during bacterial infection, we are developing two novel therapeutic strategies to selectively target the relevant nerves to enhance host defense and synergize with antimicrobial treatments. Targeting nerves can enable treatment of a broad range of pathogens through a mechanism that is not subject to antibiotic resistance.

The team is seeking input regarding the relative value of various target clinical indications, product strategy, and potential partnership priorities.